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Literature summary extracted from

  • Brocklehurst, K.; Baines, B.S.; Kierstan, M.P.J.
    Papain and other constituents of Carica papaya L (1981), Top. Enzyme Ferment. Biotechnol., 5, 262-335.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.22.2 medicine used in external treatment of hard tissue, wart and scar tissue removal, acne treatment, depilation, skin cleansing treatment, inclusing in toothpaste. Papain is used in preparation of Tyr derivatives which are used for treatment of Parkinsonism and for the preparation of tetanus vaccines and immunoglobulin samples for intravenous injection Carica papaya
3.4.22.2 nutrition papain is used in the preparation of fish protein concentrates from fish waste Carica papaya
3.4.22.2 nutrition used in the tenderisation of meat by its action on connective tissue and muscle protein. Beef is the only meat that is routinely subjected to papain tenderisation and the application of this technology is almost exclusively restricted to the USA Carica papaya
3.4.22.2 nutrition the enzyme is used for the development of roast beef-like flavours by partial hydrolysis of proteins Carica papaya
3.4.22.2 nutrition production of dehydrated pulses and beans Carica papaya

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.2 20700
-
 enzyme from commercial chymopapain, equilibrium measurement Carica papaya
3.4.22.2 23406
-
 x * 23406, calculation from amino acid sequence Carica papaya
3.4.22.2 23800
-
 enzyme from spray-dried latex, equilibrium measurement Carica papaya

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.2 Carica papaya
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.2 side-chain modification propapain is a thio-containing but catalytically inactive protein, that is a structural isomer of papain that can be transformed into papain by thiol-disulfide interchange initiated by addition of a suitable nucleophile such as thiolate Carica papaya

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.2
-
 Carica papaya

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.2 latex
-
 Carica papaya
-

Subunits

EC Number Subunits Comment Organism
3.4.22.2 ? x * 23406, calculation from amino acid sequence Carica papaya